Biological damage of ionizing radiation
    

    
    
    


        

Biological damage of ionizing radiation

Introduction

The main idea is to provide a conceptual bases DNA repair mechanisms. Because DNA uniquely serves as a permanent copy of the cell genome, however, changes in its structure are of much greater consequence than are alterations in other cell components, such as RNAs or proteins. Mutations can result from the incorporation of incorrect bases during DNA replication.

Objectives

In this activity you will explore the main mechanisms of repair of DNA damage. You will also consider the knowledge about chromosomal aberration and gene mutation.



Activity 1: DNA repair mechanisms.

This activity will help you to summarize the knowledge about DNA repair mechanism.

Instruction

Please, watch this Vidio-presentation. After that look at each of these statements and сhoose the correct answer. Then read the feedback.

 

1. If a part of a chromosome breaks and reattaches to another chromosome it is known as?





2. What is the DNA-repair process where enzymes remove a damaged portion of DNA, synthesize a replacement section in place, attach it to the neighboring DNA segments and breaks covalent bonds to take out chunks of DNA?




3. What mechanism is repair the double stranded breaks in DNA by directly ligated the broken ends without need for a homologous template.




Additional Resources

DNA Repair: https://www.ncbi.nlm.nih.gov/books/NBK9900/

Activity 2: Chromosomal aberration and gene mutation.

This activity will help you to learn the difference between chromosomal aberration and gene mutation.

Instruction

Please, read this Article. After that look at each of these statements and decide if they are true or false. Then read the feedback.

 

1. In circular DNA, the DNA molecule is shortened during replication.



2. Nondisjunction is when sister chromatids fail to separate during anaphase of cell division.Nondisjunction is when sister chromatids fail to separate during anaphase of cell division.



3. Mutation is usually a random, nonadaptive process.



Additional Resources

Chromosomal Mutations: https://www.youtube.com/watch?v=twVuIZTsY4U

© Irina Miloichikova / National Research Tomsk Polytechnic University / June 2017

Created using the LOC Tool, University of Southampton